TWO-DAY CELLULAR REVITALIZATION CYCLE*
SENOTHERAPEUTICS: UNLOCKING THE SECRETS OF AGING
Senotherapeutics are a rapidly emerging treatment within the field of anti-aging research. As we get older, our immune system slows down, leading to an accumulation of senescent cells. These cells impair the function of healthy cells, affecting our resilience to stress and illness. They are a major driver of age-related chronic disease and geriatric syndromes, including cognitive decline. Senotherapeutics, including senolytics and senomorphics, are designed to target and eliminate these senescent cells, supporting the regeneration of new tissue. One of the most promising senotherapeutics currently being studied today is D+Q, a combination of Dasatinib and Quercetin.
WHAT IS THE D+Q TREATMENT?
The D+Q senolytic treatment combines Dasatinib, a powerful tyrosine kinase inhibitor commonly used to treat leukemia, and Quercetin, a naturally occurring flavonoid with potent antioxidant properties. In 2019, the first human clinical trial revealed that D+Q can also significantly reduce age-related declines in humans. Interestingly, the combination has also demonstrated therapeutic potential in managing long COVID-19 symptoms. Additional trials with D+Q have shown progress in moderating the progression of Alzheimer's disease, reversing damage from traumatic brain injury (TBI), and even reversing down syndrome cells in vitro. It is also thought to contribute to skin rejuvenation through its selective elimination of senescent cells. This powerful combination works by targeting adverse signalling pathways associated with aging. These pathways consist of what are called tyrosine kinase enzymes and receptors. D+Q is known to slow down (inhibit) these specific pathways (shown in the table below).
NATURAL KINASE INHIBITORS: COMPOUNDS THAT TARGET THE SAME PATHWAYS AS dasatinib
A 2020 research finding demonstrated that certain compounds, isolated from natural sources, can target many of the same pathways as Dasatinib. Several studies have examined what are called "nutritional" senolytics, and concluded that they can also exhibit potent senotherapeutic properties. This research inspired the development of a natural mimetic to the D+Q treatment, leading to the creation of NEUROmergence®.
NEUROmergence® is formulated with natural ingredients shown in research to act on many of the same pathways as D+Q, one of the most advanced and recent combinations in anti-aging science. Additionally, several compounds found in NEUROmergence® have demonstrated the ability to promote the regulation and activation of AMPK*. A 2015 study indicated that activation of AMPK can successfully delay aging.
NEUROmergence® is a powerful two-day regimen to support the fight against aging and cognitive decline, by promoting the elimination of senescent cells*. This helps your body's natural cleanup process, clearing out worn-out cells so healthier ones can thrive. The product has been praised as a unique and well tolerated alternative to D+Q, formulated with compounds known to have excellent safety profiles. This innovative approach in product development has made advanced senotherapeutic support widely available for everyone.* Many users report feeling clearner, more focused, and energized. Over time, clearing senescent cells may help maintain youthful energy, brain function and overall vitality.*
WHAT IS IN NEUROMERGENCE®?
 |
Quercetin
Sophora japonica
Quercetin is a flavonoid found in apples, onions, and berries, known for its antioxidant and anti-inflammatory effects. It is thought to support immune health, cardiovascular function, and help reduce senescent cells associated with aging. Research shows quercetin blocks survival pathways used by damaged cells, including members of the SRC family and BCL-2. These actions overlap with Dasatinib’s D+Q pathway targets. |
 |
Senna
Cassia angustifolia (standardized to 70% Sennoside B)
Senna is best known as a natural laxative, but its active compound sennoside B is thought to also protect tissue, support muscle function, and maintain blood-brain barrier integrity as we age. It has shown to reduce harmful signaling through the PDGFR-β pathway, which is linked to fibrosis, fat buildup, and poor healing. This same pathway is a key target of dasatinib, making sennoside B fundamental in formulating a Dasatinib mimetic.* |
 |
Fisetin
Cotinus coggygria
Fisetin, found in strawberries and apples, is considered one of the most promising natural senotherapeutics. Studies suggest it helps the body clear senescent cells, reduces inflammation, and supports brain and metabolic health as we age. Mechanistically, fisetin acts on AMPK, mTOR, and CDK pathways, which overlap with dasatinib’s senolytic signaling targets.* |
 |
Spermidine
Oryza sativa
Spermidine is a natural compound in foods like wheat germ and soy, shown in human studies to support heart, brain, and immune health. It helps trigger autophagy, the body’s cellular “cleanup” process that clears damaged parts of cells. Spermidine also blocks SRC family kinases (SRC, FYN, LYN) and BCL-2 enzymes, overlapping with dasatinib’s D+Q activity against senescent cells.* |
 |
Pterostilbene
Vaccinium caesariense
Pterostilbene, a potent antioxidant from blueberries and grapes, absorbs better than resveratrol and supports healthy metabolism, brain, and heart aging. Recent studies show it reduces activity in the BCR-ABL pathway and suppresses AKT and NF-κB signaling, helping clear out damaged cells. These same pathways are central to the underlying mechanisms of Dasatinib.* |
 |
Ku Shen
Sophora flavescens (standardized to 40% Oxymatrine / 20% Lupeol)
Our Ku Shen extract is standardized for 40% oxymatrine and 20% lupeol. Oxymatrine has been shown to act on aging-related pathways like BCL-2, PDGFR, TGF-β/Smad, and NF-κB, which are linked to fibrosis and inflammation. Lupeol overlaps by regulating the BCL-2/Bax pathway and suppressing NF-κB, shifting cells toward healthier turnover. These combined effects align Ku Shen with Dasatinib’s anti-aging pathways.* |
 |
Berberine
Coptis chinensis
Berberine is a plant compound studied for its role in metabolic and cardiovascular support, including blood sugar balance and improved energy use in cells. It activates AMPK to promote autophagy and mitochondrial health. Berberine also inhibits kinases such as CSF1R, KIT, PIK3CD, and ROCK2, overlapping with dasatinib’s activity on inflammatory and survival pathways.* |
 |
Rutin
Sophora japonica
Rutin is a flavonoid found in buckwheat, citrus, and green tea, valued for its antioxidant, vascular, and skin-support properties. It helps improve collagen structure, circulation, and reduce harmful signals from senescent cells. Rutin also inhibits c-Met kinase, a pathway connected to inflammation and survival signals, overlapping with dasatinib’s kinase targets. |
Pathway Inhibition — D+Q Combination vs. NEUROmergence®
| Pathway / Target | Details | D+Q** | NEUROmergence |
|---|---|---|---|
| BCR-Abl | Abl tyrosine kinase | ✓ | ✓ |
| SRC Family Kinases |
D+Q:
NEUROmergence:
|
✓ | Partial |
| c-KIT |
Downstream Pathways:
|
✓ | ✓ |
| c-Met | MET/HGF receptor | ✓ | ✓ |
| CSF1R | Colony-stimulating factor 1 receptor | ✓ | ✓ |
| BCL-2 | Anti-apoptotic regulator | ✓ | ✓ |
| CDK2 | Cell-cycle kinase | ✓ | ✓ |
| EphA2 | Ephrin receptor A2 | ✓ | ✓ |
| PDGFR |
Isoforms:
|
✓ | (β only) |
This comparison reflects established pathway interactions for D+Q alongside research-based data on the ingredients found in NEUROmergence®.
Read the full research paper on NEUROmergence®
SUGGESTED PRODUCT USAGE
MDS Labs® recommends an intermittent dosing strategy to effectively support a decrease in the senescent cell burden.* Take 2–6 capsules daily for just two days, then pause for 10–15 days. This cycle can be repeated once or twice a month. Simple, powerful, and designed to fit into your lifestyle.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
For any additional information, please reach out to:
support@mdslabs.shop
ABOUT MDS LABS
TWO-DAY CELLULAR REVITALIZATION CYCLE*
- Broad-spectrum senolytic and senomorphic support formula
- Includes compounds targeting same anti-aging pathways as D+Q senolytic*
- Supports cognitive function and long-term neuroprotection*
- Promotes clearer thinking and sharper memory recall*
- Boosts youthful energy and daily vitality*
- Encourages graceful aging and overall wellness*
- Aids skin rejuvenation and healthy appearance*
SENOTHERAPEUTICS: UNLOCKING THE SECRETS OF AGING
Senotherapeutics are a rapidly emerging treatment within the field of anti-aging research. As we get older, our immune system slows down, leading to an accumulation of senescent cells. These cells impair the function of healthy cells, affecting our resilience to stress and illness. They are a major driver of age-related chronic disease and geriatric syndromes, including cognitive decline. Senotherapeutics, including senolytics and senomorphics, are designed to target and eliminate these senescent cells, supporting the regeneration of new tissue. One of the most promising senotherapeutics currently being studied today is D+Q, a combination of Dasatinib and Quercetin.
WHAT IS THE D+Q TREATMENT?
The D+Q senolytic treatment combines Dasatinib, a powerful tyrosine kinase inhibitor commonly used to treat leukemia, and Quercetin, a naturally occurring flavonoid with potent antioxidant properties. In 2019, the first human clinical trial revealed that D+Q can also significantly reduce age-related declines in humans. Interestingly, the combination has also demonstrated therapeutic potential in managing long COVID-19 symptoms. Additional trials with D+Q have shown progress in moderating the progression of Alzheimer’s disease, reversing damage from traumatic brain injury (TBI), and even reversing down syndrome cells in vitro. It is also thought to contribute to skin rejuvenation through its selective elimination of senescent cells. This powerful combination works by targeting adverse signalling pathways associated with aging. These pathways consist of what are called tyrosine kinase enzymes and receptors. D+Q is known to slow down (inhibit) these specific pathways (shown in the table below).
NATURAL KINASE INHIBITORS: COMPOUNDS THAT TARGET THE SAME PATHWAYS AS dasatinib
A 2020 research finding demonstrated that certain compounds, isolated from natural sources, can target many of the same pathways as Dasatinib. Several studies have examined what are called “nutritional” senolytics, and concluded that they can also exhibit potent senotherapeutic properties. This research inspired the development of a natural mimetic to the D+Q treatment, leading to the creation of NEUROmergence®.
NEUROmergence® is formulated with natural ingredients shown in research to act on many of the same pathways as D+Q, one of the most advanced and recent combinations in anti-aging science. Additionally, several compounds found in NEUROmergence® have demonstrated the ability to promote the regulation and activation of AMPK*. A 2015 study indicated that activation of AMPK can successfully delay aging.
NEUROmergence® is a powerful two-day regimen to support the fight against aging and cognitive decline, by promoting the elimination of senescent cells*. This helps your body’s natural cleanup process, clearing out worn-out cells so healthier ones can thrive. The product has been praised as a unique and well tolerated alternative to D+Q, formulated with compounds known to have excellent safety profiles. This innovative approach in product development has made advanced senotherapeutic support widely available for everyone.* Many users report feeling clearner, more focused, and energized. Over time, clearing senescent cells may help maintain youthful energy, brain function and overall vitality.*
WHAT IS IN NEUROMERGENCE®?
|
Quercetin
|
|
Senna
|
|
Fisetin
|
|
Spermidine
|
|
Pterostilbene
|
|
Ku Shen
|
|
Berberine
|
|
Rutin
|
Pathway Inhibition — D+Q Combination vs. NEUROmergence®
| Pathway / Target | Details | D+Q** | NEUROmergence |
|---|---|---|---|
| BCR-Abl | Abl tyrosine kinase | ✓ | ✓ |
| SRC Family Kinases |
D+Q:
NEUROmergence:
|
✓ | Partial |
| c-KIT |
Downstream Pathways:
|
✓ | ✓ |
| c-Met | MET/HGF receptor | ✓ | ✓ |
| CSF1R | Colony-stimulating factor 1 receptor | ✓ | ✓ |
| BCL-2 | Anti-apoptotic regulator | ✓ | ✓ |
| CDK2 | Cell-cycle kinase | ✓ | ✓ |
| EphA2 | Ephrin receptor A2 | ✓ | ✓ |
| PDGFR |
Isoforms:
|
✓ | (β only) |
This comparison reflects established pathway interactions for D+Q alongside research-based data on the ingredients found in NEUROmergence®.
Read the full research paper on NEUROmergence®
SUGGESTED PRODUCT USAGE
MDS Labs® recommends an intermittent dosing strategy to effectively support a decrease in the senescent cell burden.* Take 2–6 capsules daily for just two days, then pause for 10–15 days. This cycle can be repeated once or twice a month. Simple, powerful, and designed to fit into your lifestyle.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
For any additional information, please reach out to:
support@mdslabs.shop
ABOUT MDS LABS