Ku Shen Extract
(Sophora flavescens, 40% Oxymatrine / 20% Lupeol)
250mg Capsules
Sophora flavescens: Lupeol and Its Researched Longevity Properties*
Sophora flavescens, or Ku Shen, is used in traditional Chinese medicine and contains several bioactive compounds of research interest, including Lupeol, a pentacyclic triterpenoid.* Lupeol has been studied for a broad range of properties, including anti-inflammatory and antioxidant effects.* Its first total synthesis was reported by Gilbert Stork in 1971 [1]. In one study, Lupeol and its derivatives showed higher anti-inflammatory activity than the non-steroidal anti-inflammatory compound indomethacin in a research setting.* [2]
By supporting the body against oxidative stress and modulating inflammation — both processes studied in connection with aging — Lupeol is researched for its potential role in healthy aging.*
Lupeol: Skin Benefits and Senolytic Potential*
Research has explored whether Lupeol may support skin health by influencing enzymes involved in the skin's extracellular matrix, an area studied in relation to skin appearance and elasticity.*
Lupeol has also been studied for a potential role in longevity through its effect on cellular senescence — the process in which cells stop dividing as they age and accumulate damage.* Its researched senolytic activity has been linked to inhibition of the CDK1, CDK2, CDK4, CDK5, and CDK6 kinase enzymes, and to activity on MAPK kinase signaling.*
A Millennia-Old Botanical in Traditional Chinese Medicine
Ku Shen has a rich history in traditional Chinese medicine (TCM) spanning over two millennia, where it was valued as a "heat-clearing" and "dampness-drying" herb according to TCM principles.* Its bitter taste and cooling character made it a common component of traditional formulations. Today, modern research continues to study the diverse pharmacology of Ku Shen's bioactive compounds, including their anti-inflammatory and antioxidant properties.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Stork G, Uyeo S, Wakamatsu T, Grieco P, Labovitz J (1971). "Total synthesis of lupeol". Journal of the American Chemical Society. 93 (19): 4945. doi:10.1021/ja00748a068.
https://doi.org/10.1021%2Fja00748a068
[2] Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 2009 Nov 28;285(2):109-15. doi: 10.1016/j.canlet.2009.04.033. Epub 2009 May 22. PMID: 19464787; PMCID: PMC2764818.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764818/
Ku Shen Extract
(Sophora flavescens, 40% Oxymatrine / 20% Lupeol)
250mg Capsules
- Includes 250mg per capsule of Ku Shen Extract (Sophora flavescens)
- Standardized to 40% Oxymatrine / 20% Lupeol
- Natural, Gluten Free, Vegan, Non GMO
- Every batch HPLC tested for purity
- Includes 20 Capsules
- Free US Shipping
Sophora flavescens: Lupeol and Its Researched Longevity Properties*
Sophora flavescens, or Ku Shen, is used in traditional Chinese medicine and contains several bioactive compounds of research interest, including Lupeol, a pentacyclic triterpenoid.* Lupeol has been studied for a broad range of properties, including anti-inflammatory and antioxidant effects.* Its first total synthesis was reported by Gilbert Stork in 1971 [1]. In one study, Lupeol and its derivatives showed higher anti-inflammatory activity than the non-steroidal anti-inflammatory compound indomethacin in a research setting.* [2]
By supporting the body against oxidative stress and modulating inflammation — both processes studied in connection with aging — Lupeol is researched for its potential role in healthy aging.*
Lupeol: Skin Benefits and Senolytic Potential*
Research has explored whether Lupeol may support skin health by influencing enzymes involved in the skin’s extracellular matrix, an area studied in relation to skin appearance and elasticity.*
Lupeol has also been studied for a potential role in longevity through its effect on cellular senescence — the process in which cells stop dividing as they age and accumulate damage.* Its researched senolytic activity has been linked to inhibition of the CDK1, CDK2, CDK4, CDK5, and CDK6 kinase enzymes, and to activity on MAPK kinase signaling.*
A Millennia-Old Botanical in Traditional Chinese Medicine
Ku Shen has a rich history in traditional Chinese medicine (TCM) spanning over two millennia, where it was valued as a “heat-clearing” and “dampness-drying” herb according to TCM principles.* Its bitter taste and cooling character made it a common component of traditional formulations. Today, modern research continues to study the diverse pharmacology of Ku Shen’s bioactive compounds, including their anti-inflammatory and antioxidant properties.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Stork G, Uyeo S, Wakamatsu T, Grieco P, Labovitz J (1971). “Total synthesis of lupeol”. Journal of the American Chemical Society. 93 (19): 4945. doi:10.1021/ja00748a068.
https://doi.org/10.1021%2Fja00748a068
[2] Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 2009 Nov 28;285(2):109-15. doi: 10.1016/j.canlet.2009.04.033. Epub 2009 May 22. PMID: 19464787; PMCID: PMC2764818.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764818/
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