Pure Fisetin 400mg — Senolytic & Longevity Support* Capsules

Fisetin: Powerful Senotherapeutic Potential*

Fisetin is a bioactive flavonol found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber. Several studies have reported fisetin to have neurotrophic, antioxidant, and anti-inflammatory properties.* [1] Its researched anti-aging activity is thought to come from its ability to target cells that have undergone a process called senescence.* Senescence is when a cell ages and permanently stops dividing but does not die. Over time, these cells build up in tissues throughout the body and can release substances that promote inflammation and affect nearby healthy cells.

Fisetin is an active area of senolytic research. Studies have included work on its senolytic activity alongside the D+Q combination (Dasatinib and Quercetin), and ongoing human research is exploring senolytics in various populations. In a longitudinal study that measured biological age using DNA methylation clocks, researchers examined the effects of D+Q and fisetin on senolytic-related markers.* [2]

natural compounds studied for senolytic activity

A 2018 study [3] set out to test ten flavonoids for senolytic properties. The researchers noted that D+Q is a potent senolytic studied in the context of several age-related conditions, and aimed to identify natural flavonoids with even greater senolytic activity.

The study examined human fibroblasts that had become senescent through oxidative and genotoxic stress, and further tested the flavonoids in mice, evaluating age-related histopathology, disease markers, health span, and lifespan. Of the 10 flavonoids tested, fisetin was the most potent senolytic.* Fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism.* The authors reported that fisetin showed senotherapeutic activity in both human and mouse tissue, and that in mice, fisetin improved tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.* Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans.

the science behind fisetin

Fisetin has been studied for its activity on the AMPK, MAPK, and mTOR pathways, and for inhibition of the CDK1 and CDK4 kinase enzymes.* [4] A 2015 study examined how AMPK activation relates to aging [5], while a 2019 review described mTOR's role as a central regulator of lifespan and aging across a wide range of organisms.* [6]

mTOR is a protein kinase that helps regulate cellular metabolism, autophagy, survival, proliferation, and other processes involved in cellular homeostasis. It is the target of the compound Rapamycin, which is noted in the literature as the compound most consistently shown to extend mammalian lifespan. Some studies have explored whether other natural compounds, including fisetin, may also act on mTOR.*

fisetin's role in the NEUROmergence® formulation*

Several natural senolytic supplements are available today. NEUROmergence®, which contains fisetin, was formulated with seven additional compounds researched on some of the same pathways reported to be inhibited by Dasatinib.* NEUROmergence® also includes Quercetin, one of the two compounds in the Dasatinib + Quercetin combination.* The formulation was built by mapping those researched pathways and selecting well-tolerated natural compounds studied on many of them.* Every ingredient in NEUROmergence® is also available individually, in capsule and powder form.

ATTENTION:

If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.

* These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure, or prevent any disease.

Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.

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CITATIONS:

[1] Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/

[2] Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024 Feb 22; 16:3088-3106.
https://doi.org/10.18632/aging.205581

[3] Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.
https://pubmed.ncbi.nlm.nih.gov/30279143/

[4] Baier A, Szyszka R. Compounds from Natural Sources as Protein Kinase Inhibitors. Biomolecules. 2020 Nov 12;10(11):1546. doi: 10.3390/biom10111546. PMID: 33198400; PMCID: PMC7698043.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698043/

[5] Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941559/

[6] Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. mTOR as a central regulator of lifespan and aging. F1000Res. 2019 Jul 2;8:F1000 Faculty Rev-998. doi: 10.12688/f1000research.17196.1. PMID: 31316753; PMCID: PMC6611156.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/