Researched for AMPK Activation and Cellular Renewal*
Berberine, a bioactive compound extracted from several plants such as Coptis chinensis and Berberis vulgaris (barberry), has drawn attention for its potential role in healthy aging. One of berberine's most-studied mechanisms is its activation of AMP-activated protein kinase (AMPK), often called a "metabolic master switch."* [1] AMPK activation is studied for its role in metabolic efficiency and energy balance, processes that are central to aging research. Research has also explored AMPK's connection to mitochondrial function and to autophagy — the body's process for clearing damaged cellular components and supporting cellular renewal.*
Metabolic Health Support*
Berberine is one of the more extensively studied natural compounds for metabolic health.* Research has explored its role in supporting healthy insulin sensitivity, blood sugar balance, and lipid metabolism — all of which are studied in connection with healthy aging.*
A notable quality of berberine is its researched activity on several kinase pathways. In a 2023 in-silico (computational) study, berberine was predicted to have high binding affinity for ROCK2, PIK3CD, KCNMA1, CSF1R, and KIT, and the authors suggested berberine may act more like a natural tyrosine kinase inhibitor than a metabolic drug.* [2] CSF1R is one of the pathways also targeted by Dasatinib, and berberine's researched association with CSF1R is why it was selected for NEUROmergence®.*
A Millennia-Old Remedy in Traditional Chinese Medicine
Berberine has been used in traditional medicine systems for centuries. Its use dates back over 2,000 years in ancient Chinese and Ayurvedic traditions, where it was valued for a broad range of applications [3]. It was a common component of traditional formulations intended to support digestive and gastrointestinal balance and overall vitality, often valued for its bitter, "heat-clearing" character. Today, modern research continues to study berberine's pharmacology, with particular interest in its role in supporting metabolic health.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Jin Y, Liu S, Ma Q, Xiao D, Chen L. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes. Eur J Pharmacol. 2017 Jan 5;794:106-114. doi: 10.1016/j.ejphar.2016.11.037. Epub 2016 Nov 22. PMID: 27887947.
https://pubmed.ncbi.nlm.nih.gov/27887947/
[2] Singh NK, Dhanasekaran M, Kumar AHS. Pharmacology of Berberine and Its Metabolites, Is It the Natures Ozempic or Imatinib? Arch Pharmacol Ther. 2023;5(1):67-81.
https://www.scientificarchives.com/article/pharmacology-of-berberine-and-its-metabolites-is-it-the-natures-ozempic-or-imatinib
[3] Anil Kumar, Ekavali, Kanwaljit Chopra, Madhurima Mukherjee, Raghavender Pottabathini, Dinesh K. Dhull, Current knowledge and pharmacological profile of berberine: An update, European Journal of Pharmacology, Volume 761, 2015, Pages 288-297, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2015.05.068.
https://www.sciencedirect.com/science/article/abs/pii/S0014299915300571
Researched for AMPK Activation and Cellular Renewal*
Berberine, a bioactive compound extracted from several plants such as Coptis chinensis and Berberis vulgaris (barberry), has drawn attention for its potential role in healthy aging. One of berberine’s most-studied mechanisms is its activation of AMP-activated protein kinase (AMPK), often called a “metabolic master switch.”* [1] AMPK activation is studied for its role in metabolic efficiency and energy balance, processes that are central to aging research. Research has also explored AMPK’s connection to mitochondrial function and to autophagy — the body’s process for clearing damaged cellular components and supporting cellular renewal.*
Metabolic Health Support*
Berberine is one of the more extensively studied natural compounds for metabolic health.* Research has explored its role in supporting healthy insulin sensitivity, blood sugar balance, and lipid metabolism — all of which are studied in connection with healthy aging.*
A notable quality of berberine is its researched activity on several kinase pathways. In a 2023 in-silico (computational) study, berberine was predicted to have high binding affinity for ROCK2, PIK3CD, KCNMA1, CSF1R, and KIT, and the authors suggested berberine may act more like a natural tyrosine kinase inhibitor than a metabolic drug.* [2] CSF1R is one of the pathways also targeted by Dasatinib, and berberine’s researched association with CSF1R is why it was selected for NEUROmergence®.*
A Millennia-Old Remedy in Traditional Chinese Medicine
Berberine has been used in traditional medicine systems for centuries. Its use dates back over 2,000 years in ancient Chinese and Ayurvedic traditions, where it was valued for a broad range of applications [3]. It was a common component of traditional formulations intended to support digestive and gastrointestinal balance and overall vitality, often valued for its bitter, “heat-clearing” character. Today, modern research continues to study berberine’s pharmacology, with particular interest in its role in supporting metabolic health.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Jin Y, Liu S, Ma Q, Xiao D, Chen L. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes. Eur J Pharmacol. 2017 Jan 5;794:106-114. doi: 10.1016/j.ejphar.2016.11.037. Epub 2016 Nov 22. PMID: 27887947.
https://pubmed.ncbi.nlm.nih.gov/27887947/
[2] Singh NK, Dhanasekaran M, Kumar AHS. Pharmacology of Berberine and Its Metabolites, Is It the Natures Ozempic or Imatinib? Arch Pharmacol Ther. 2023;5(1):67-81.
https://www.scientificarchives.com/article/pharmacology-of-berberine-and-its-metabolites-is-it-the-natures-ozempic-or-imatinib
[3] Anil Kumar, Ekavali, Kanwaljit Chopra, Madhurima Mukherjee, Raghavender Pottabathini, Dinesh K. Dhull, Current knowledge and pharmacological profile of berberine: An update, European Journal of Pharmacology, Volume 761, 2015, Pages 288-297, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2015.05.068.
https://www.sciencedirect.com/science/article/abs/pii/S0014299915300571
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