Full Spectrum Senna Leaf Extract
Cassia angustifolia Standardized to 20% Sennocide B
- Sennoside B inhibits the PDGF and PDGFR-β pathways, which play key roles in aging. This action may counteract factors like excess fat and fibrosis, supporting better muscle function and faster healing.
- By reducing PDGFR-β signaling, sennoside B helps preserve blood-brain barrier integrity, potentially reducing age-related neuroinflammation and dementia risks.
Senna: More than just Nature's Laxative
Senna is derived from the leaves and fruit of the senna plant Cassia angustifolia, and is renowned for its powerful laxative properties. Its use dates back to 3150 BCE, and was even found in ancient Egyptian pottery jars. Its laxative properties come from compounds called sennosides, which stimulate the bowel lining to help relieve constipation- a common issue that tends to increase with age. Keeping your digestive system healthy is essential for overall well-being. However, senna has fascinating medicinal properties that far exceed that of just a laxative.
The two major active compounds in senna are sennoside A and sennoside B. They have both been shown to have significant gastroprotective activities by increasing prostaglandin E2, and have also demonstrated the ability to reduce gastric acid. [1]
Powerful Anti-aging Properties through Inhibition of PDGFR-β
The anti-aging properties of sennosides have been the subject of several recent studies. It has proven to be a potent inhibitor of PDGF and PDGFR-β, even when taken orally as a supplement. [2] PDGF stands for platelet-derived growth factor, and is a signaling pathway crucial in connective tissue development. PDGFR-β is a specific receptor for PDGF, and plays a major role in why we age.
When we are young, PDGFR-β lineage cells contribute to muscle regeneration. However, as we age, they switch roles, contributing to negative growth factors such as adipose tissue (associated with insulin resistance and muscle dysfunction), as well as fibrotic tissue, also known as fibrosis (scar tissue). When we reach our forties and beyond, excess PDGFR- β signaling reduces our body's ability to heal properly from injuries. [3]
Why is Excess PDGFR-β Signaling Problematic?
PDGFR-β expression was found to contribute to age-related blood-brain barrier damage leading to dementia. Higher CSF PDGFR-β concentrations were found to increase CSF neuroinflammatory markers of glial activation and worse blood-brain barrier integrity. [4]
Premature aging syndrome is characterized by a lack of fatty tissue under the skin. This lack of fat, together with thin, wrinkled skin and veins visible beneath the skin, makes affected individuals look older than their biological age. This condition is a gene mutation that causes increased PDGFR-β. Several other diseases are also linked to increased PDGFR-β, including chronic eosinophilic leukemia and familial brain calcification. [5]
Sennocide B is vital to the neuromergence® formulation
The potential to reduce excess PDGFR-β signaling just by taking a sennocide B supplement is a major breakthrough in anti-aging science. NEUROmergence® Senolytic by MDS Labs® is a new product designed to support increased longevity, and was specifically formulated with ingredients known to inhibit the same cellular pathways as the powerful D+Q senolytic treatment (a combination of Dasatinib and Quercetin), including PDGFR-β. Inhibiting these specific pathways has demonstrated the ability to slow dementia, reduce long-COVID-19 neuropathy, and even improve skin elasticity in clinical trials.
Sennocide B was included in this formulation to further align NEUROmergence as a D+Q mimetic supplement. PDGFR-β is one of the key pathways targeted by Dasatinib, which was first developed as a cancer fighting smart drug. NEUROmergence is the only senolytic supplement to demonstrate its effectiveness through Western blotting, which was a key metric during the development phase.
Sennocides also have Antiviral Properties
Interestingly, sennosides are also known to have antiviral properties. In one study, they demonstrated the ability to interact with HIV-1 CA assembly, altering the course of a viral infection. HIV-1 CA assembly is a cone-shaped protein shell that surrounds the HIV virus, housing its viral genome. The author concluded that these compounds show potential for developing new anti-HIV-1 inhibitors. [6]
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
ABOUT MDS LABS
CITATIONS:
[1] Hwang IY, Jeong CS. Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase. Biomol Ther (Seoul). 2015 Sep;23(5):458-64. doi: 10.4062/biomolther.2015.052. Epub 2015 Sep 1. PMID: 26336586; PMCID: PMC4556206.
[2] Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22. doi: 10.1016/j.lfs.2009.04.003. Epub 2009 Apr 22. PMID: 19393247.
[3] Benvie, A.M., Lee, D., Steiner, B.M. et al. Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun 14, 1806 (2023). https://doi.org/10.1038/s41467-023-37386-z
[4] Cicognola C, Mattsson-Carlgren N, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Ahmadi K, Strandberg O, Stomrud E, Janelidze S, Hansson O. Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes. Neurology. 2023 Jul 4;101(1):e30-e39. doi: 10.1212/WNL.0000000000207358. Epub 2023 May 3. PMID: 37137722; PMCID: PMC10351311.
[5] MedlinePlus [Internet]: PDGFRB gene; platelet derived growth factor receptor beta. Available from: https://medlineplus.gov/genetics/gene/pdgfrb/#conditions
[6] Zhang DW, Xu XS, Zhou R, Fu Z. Modulation of HIV-1 capsid multimerization by sennoside A and sennoside B via interaction with the NTD/CTD interface in capsid hexamer. Front Microbiol. 2023 Sep 25;14:1270258. doi: 10.3389/fmicb.2023.1270258. PMID: 37817748; PMCID: PMC10561090.
Full Spectrum Senna Leaf Extract
Cassia angustifolia Standardized to 20% Sennocide B
- Sennoside B inhibits the PDGF and PDGFR-β pathways, which play key roles in aging. This action may counteract factors like excess fat and fibrosis, supporting better muscle function and faster healing.
- By reducing PDGFR-β signaling, sennoside B helps preserve blood-brain barrier integrity, potentially reducing age-related neuroinflammation and dementia risks.
Senna: More than just Nature’s Laxative
Senna is derived from the leaves and fruit of the senna plant Cassia angustifolia, and is renowned for its powerful laxative properties. Its use dates back to 3150 BCE, and was even found in ancient Egyptian pottery jars. Its laxative properties come from compounds called sennosides, which stimulate the bowel lining to help relieve constipation- a common issue that tends to increase with age. Keeping your digestive system healthy is essential for overall well-being. However, senna has fascinating medicinal properties that far exceed that of just a laxative.
The two major active compounds in senna are sennoside A and sennoside B. They have both been shown to have significant gastroprotective activities by increasing prostaglandin E2, and have also demonstrated the ability to reduce gastric acid. [1]
Powerful Anti-aging Properties through Inhibition of PDGFR-β
The anti-aging properties of sennosides have been the subject of several recent studies. It has proven to be a potent inhibitor of PDGF and PDGFR-β, even when taken orally as a supplement. [2] PDGF stands for platelet-derived growth factor, and is a signaling pathway crucial in connective tissue development. PDGFR-β is a specific receptor for PDGF, and plays a major role in why we age.
When we are young, PDGFR-β lineage cells contribute to muscle regeneration. However, as we age, they switch roles, contributing to negative growth factors such as adipose tissue (associated with insulin resistance and muscle dysfunction), as well as fibrotic tissue, also known as fibrosis (scar tissue). When we reach our forties and beyond, excess PDGFR- β signaling reduces our body’s ability to heal properly from injuries. [3]
Why is Excess PDGFR-β Signaling Problematic?
PDGFR-β expression was found to contribute to age-related blood-brain barrier damage leading to dementia. Higher CSF PDGFR-β concentrations were found to increase CSF neuroinflammatory markers of glial activation and worse blood-brain barrier integrity. [4]
Premature aging syndrome is characterized by a lack of fatty tissue under the skin. This lack of fat, together with thin, wrinkled skin and veins visible beneath the skin, makes affected individuals look older than their biological age. This condition is a gene mutation that causes increased PDGFR-β. Several other diseases are also linked to increased PDGFR-β, including chronic eosinophilic leukemia and familial brain calcification. [5]
Sennocide B is vital to the neuromergence® formulation
The potential to reduce excess PDGFR-β signaling just by taking a sennocide B supplement is a major breakthrough in anti-aging science. NEUROmergence® Senolytic by MDS Labs® is a new product designed to support increased longevity, and was specifically formulated with ingredients known to inhibit the same cellular pathways as the powerful D+Q senolytic treatment (a combination of Dasatinib and Quercetin), including PDGFR-β. Inhibiting these specific pathways has demonstrated the ability to slow dementia, reduce long-COVID-19 neuropathy, and even improve skin elasticity in clinical trials.
Sennocide B was included in this formulation to further align NEUROmergence as a D+Q mimetic supplement. PDGFR-β is one of the key pathways targeted by Dasatinib, which was first developed as a cancer fighting smart drug. NEUROmergence is the only senolytic supplement to demonstrate its effectiveness through Western blotting, which was a key metric during the development phase.
Sennocides also have Antiviral Properties
Interestingly, sennosides are also known to have antiviral properties. In one study, they demonstrated the ability to interact with HIV-1 CA assembly, altering the course of a viral infection. HIV-1 CA assembly is a cone-shaped protein shell that surrounds the HIV virus, housing its viral genome. The author concluded that these compounds show potential for developing new anti-HIV-1 inhibitors. [6]
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
ABOUT MDS LABS
CITATIONS:
[1] Hwang IY, Jeong CS. Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase. Biomol Ther (Seoul). 2015 Sep;23(5):458-64. doi: 10.4062/biomolther.2015.052. Epub 2015 Sep 1. PMID: 26336586; PMCID: PMC4556206.
[2] Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22. doi: 10.1016/j.lfs.2009.04.003. Epub 2009 Apr 22. PMID: 19393247.
[3] Benvie, A.M., Lee, D., Steiner, B.M. et al. Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun 14, 1806 (2023). https://doi.org/10.1038/s41467-023-37386-z
[4] Cicognola C, Mattsson-Carlgren N, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Ahmadi K, Strandberg O, Stomrud E, Janelidze S, Hansson O. Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes. Neurology. 2023 Jul 4;101(1):e30-e39. doi: 10.1212/WNL.0000000000207358. Epub 2023 May 3. PMID: 37137722; PMCID: PMC10351311.
[5] MedlinePlus [Internet]: PDGFRB gene; platelet derived growth factor receptor beta. Available from: https://medlineplus.gov/genetics/gene/pdgfrb/#conditions
[6] Zhang DW, Xu XS, Zhou R, Fu Z. Modulation of HIV-1 capsid multimerization by sennoside A and sennoside B via interaction with the NTD/CTD interface in capsid hexamer. Front Microbiol. 2023 Sep 25;14:1270258. doi: 10.3389/fmicb.2023.1270258. PMID: 37817748; PMCID: PMC10561090.
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