Full Spectrum Senna Leaf Extract
Cassia angustifolia (Standardized to 70% Sennoside B)
- Sennoside B has been studied for its activity on the PDGF and PDGFR-β signaling pathways, which are an active area of aging research.*
- In laboratory research, sennoside B was shown to bind PDGF-BB and the PDGF-β receptor and to reduce PDGFR-β signaling.*
Senna: More than just Nature's Laxative*
Senna is derived from the leaves and fruit of the senna plant Cassia angustifolia, and is renowned for its laxative properties. Its use dates back to 3150 BCE, and was even found in ancient Egyptian pottery jars. Its laxative action comes from compounds called sennosides, which stimulate the bowel lining to help relieve occasional constipation — something that tends to become more common with age. Keeping your digestive system regular is part of overall well-being. But senna has also drawn research interest that goes beyond its use as a laxative.
The two major active compounds in senna are sennoside A and sennoside B. In a rat model, both were shown to have gastroprotective activity by increasing prostaglandin E2 and reducing gastric acid. [1]
Researched for Activity on the PDGFR-β Pathway
Sennoside B has been studied for its activity on the PDGF and PDGFR-β signaling pathways. In laboratory (cell-culture) research, it was found to inhibit PDGF-BB-induced PDGF receptor signaling, binding directly to both PDGF-BB and the PDGF-β receptor.* [2] PDGF stands for platelet-derived growth factor — a signaling pathway involved in connective tissue development. PDGFR-β is a specific receptor for PDGF, and it is studied extensively in the context of aging.
In early life, PDGFR-β lineage cells contribute to muscle regeneration. Research in mice suggests that with age, these cells shift roles and contribute to changes such as fat (adipose) tissue accumulation and fibrotic (scar) tissue, and that age-related PDGFR-β signaling is associated with reduced regenerative capacity. [3]
Why PDGFR-β Signaling Is Studied in Aging Research
In one study, higher cerebrospinal-fluid PDGFR-β concentrations were associated with markers of blood-brain barrier integrity and neuroinflammation in the context of aging. [4]
Researchers also study PDGFR-β because variations in the PDGFRB gene are connected to several rare genetic conditions, which is part of why the pathway is of interest in aging and tissue research. [5]
Why Sennoside B Is Part of the NEUROmergence® Formulation
Sennoside B's researched activity on the PDGFR-β pathway is what earned it a place in NEUROmergence®.* NEUROmergence® is a senolytic support supplement by MDS Labs®, formulated for cellular longevity using natural compounds that have been researched on some of the same signaling pathways studied in connection with the D+Q senolytic combination (dasatinib and quercetin) — including PDGFR-β.*
PDGFR-β is one of the pathways reported to be inhibited by dasatinib, which was originally developed as a prescription kinase inhibitor. NEUROmergence® was built by mapping those researched pathways and selecting natural compounds studied on many of them, alongside quercetin.*
ATTENTION:
Senna is intended for short-term use to relieve occasional constipation. Do not use for more than one week unless directed by a physician. If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Hwang IY, Jeong CS. Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase. Biomol Ther (Seoul). 2015 Sep;23(5):458-64. doi: 10.4062/biomolther.2015.052. Epub 2015 Sep 1. PMID: 26336586; PMCID: PMC4556206.
https://pubmed.ncbi.nlm.nih.gov/26336586/
[2] Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22. doi: 10.1016/j.lfs.2009.04.003. Epub 2009 Apr 22. PMID: 19393247.
https://pubmed.ncbi.nlm.nih.gov/19393247/
[3] Benvie, A.M., Lee, D., Steiner, B.M. et al. Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun 14, 1806 (2023).
https://doi.org/10.1038/s41467-023-37386-z
[4] Cicognola C, Mattsson-Carlgren N, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Ahmadi K, Strandberg O, Stomrud E, Janelidze S, Hansson O. Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes. Neurology. 2023 Jul 4;101(1):e30-e39. doi: 10.1212/WNL.0000000000207358. Epub 2023 May 3. PMID: 37137722; PMCID: PMC10351311.
https://pubmed.ncbi.nlm.nih.gov/37137722/
[5] MedlinePlus [Internet]: PDGFRB gene; platelet derived growth factor receptor beta. Available from: https://medlineplus.gov/genetics/gene/pdgfrb/#conditions
Full Spectrum Senna Leaf Extract
Cassia angustifolia (Standardized to 70% Sennoside B)
- Sennoside B has been studied for its activity on the PDGF and PDGFR-β signaling pathways, which are an active area of aging research.*
- In laboratory research, sennoside B was shown to bind PDGF-BB and the PDGF-β receptor and to reduce PDGFR-β signaling.*
Senna: More than just Nature’s Laxative*
Senna is derived from the leaves and fruit of the senna plant Cassia angustifolia, and is renowned for its laxative properties. Its use dates back to 3150 BCE, and was even found in ancient Egyptian pottery jars. Its laxative action comes from compounds called sennosides, which stimulate the bowel lining to help relieve occasional constipation — something that tends to become more common with age. Keeping your digestive system regular is part of overall well-being. But senna has also drawn research interest that goes beyond its use as a laxative.
The two major active compounds in senna are sennoside A and sennoside B. In a rat model, both were shown to have gastroprotective activity by increasing prostaglandin E2 and reducing gastric acid. [1]
Researched for Activity on the PDGFR-β Pathway
Sennoside B has been studied for its activity on the PDGF and PDGFR-β signaling pathways. In laboratory (cell-culture) research, it was found to inhibit PDGF-BB-induced PDGF receptor signaling, binding directly to both PDGF-BB and the PDGF-β receptor.* [2] PDGF stands for platelet-derived growth factor — a signaling pathway involved in connective tissue development. PDGFR-β is a specific receptor for PDGF, and it is studied extensively in the context of aging.
In early life, PDGFR-β lineage cells contribute to muscle regeneration. Research in mice suggests that with age, these cells shift roles and contribute to changes such as fat (adipose) tissue accumulation and fibrotic (scar) tissue, and that age-related PDGFR-β signaling is associated with reduced regenerative capacity. [3]
Why PDGFR-β Signaling Is Studied in Aging Research
In one study, higher cerebrospinal-fluid PDGFR-β concentrations were associated with markers of blood-brain barrier integrity and neuroinflammation in the context of aging. [4]
Researchers also study PDGFR-β because variations in the PDGFRB gene are connected to several rare genetic conditions, which is part of why the pathway is of interest in aging and tissue research. [5]
Why Sennoside B Is Part of the NEUROmergence® Formulation
Sennoside B’s researched activity on the PDGFR-β pathway is what earned it a place in NEUROmergence®.* NEUROmergence® is a senolytic support supplement by MDS Labs®, formulated for cellular longevity using natural compounds that have been researched on some of the same signaling pathways studied in connection with the D+Q senolytic combination (dasatinib and quercetin) — including PDGFR-β.*
PDGFR-β is one of the pathways reported to be inhibited by dasatinib, which was originally developed as a prescription kinase inhibitor. NEUROmergence® was built by mapping those researched pathways and selecting natural compounds studied on many of them, alongside quercetin.*
ATTENTION:
Senna is intended for short-term use to relieve occasional constipation. Do not use for more than one week unless directed by a physician. If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Hwang IY, Jeong CS. Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase. Biomol Ther (Seoul). 2015 Sep;23(5):458-64. doi: 10.4062/biomolther.2015.052. Epub 2015 Sep 1. PMID: 26336586; PMCID: PMC4556206.
https://pubmed.ncbi.nlm.nih.gov/26336586/
[2] Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22. doi: 10.1016/j.lfs.2009.04.003. Epub 2009 Apr 22. PMID: 19393247.
https://pubmed.ncbi.nlm.nih.gov/19393247/
[3] Benvie, A.M., Lee, D., Steiner, B.M. et al. Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice. Nat Commun 14, 1806 (2023).
https://doi.org/10.1038/s41467-023-37386-z
[4] Cicognola C, Mattsson-Carlgren N, van Westen D, Zetterberg H, Blennow K, Palmqvist S, Ahmadi K, Strandberg O, Stomrud E, Janelidze S, Hansson O. Associations of CSF PDGFRβ With Aging, Blood-Brain Barrier Damage, Neuroinflammation, and Alzheimer Disease Pathologic Changes. Neurology. 2023 Jul 4;101(1):e30-e39. doi: 10.1212/WNL.0000000000207358. Epub 2023 May 3. PMID: 37137722; PMCID: PMC10351311.
https://pubmed.ncbi.nlm.nih.gov/37137722/
[5] MedlinePlus [Internet]: PDGFRB gene; platelet derived growth factor receptor beta. Available from: https://medlineplus.gov/genetics/gene/pdgfrb/#conditions
Reviews
There are no reviews yet.