At MDS Labs®, we are frequently asked why NEUROmergence®, our D+Q mimetic supplement for broad-spectrum senolytic support, should only be taken 2-3 times a month. The reason lies in the unique nature of senotherapeutics. These compounds, including senolytics and senomorphics, work best when cycled using a “hit-and-run” dosing strategy. This approach has been shown to be the most effective in clearing senolytic (damaged) cells.

In addition to NEUROmergence®, we’re excited to introduce two new daily supplements designed to support cognitive health and anti-aging.

NEUROvantage® is a cognitive enhancement supplement that supports brain function with a blend of natural compounds, including Niacin, Vitamin B6, GABA, L-Tyrosine, Bacopa monnieri, and Huperzine A. This daily supplement promotes mental clarity, focus, and cognitive performance, using high-quality, natural ingredients without artificial additives. NEUROvantage® is the perfect daily companion to NEUROmergence® for those looking to enhance cognitive function and brain health.

NEUROfuel®, our second new release, is also formulated for cognitive and anti-aging support but includes a complete multivitamin profile. NEUROfuel® serves as an all-in-one daily brain health solution, optimized to boost mental focus, intelligence, and memory function.

Choosing the Right Supplement:

If you’re already taking a multivitamin or maintain a nutrient-rich diet, NEUROvantage® is likely your best option for cognitive enhancement. However, if you’re looking for a comprehensive, one-and-done solution that pairs well with NEUROmergence®, NEUROfuel® is the recommended choice.

Research suggests that fisetin has strong senolytic activity, which means it can selectively induce the death of senescent cells. Senescent cells are damaged cells that cease to divide but do not die as they should. They release inflammatory factors that lead to tissue dysfunction and age-related diseases, and subsequently, play a major role in the aging process. By clearing these cells, fisetin helps reduce inflammation and enhance tissue function, potentially extending lifespan and improving the quality of life in aging populations.

A 2018 study [1] set out to test ten flavonoids for their senolytic properties. The study acknowledged that the combination of Dasatinib, (when combined with the flavonoid quercetin) is a potent senolytic, improving numerous age-related conditions including frailty, osteoporosis, and cardiovascular disease. However, the goal of this study was to identify natural flavinoids with even more potent senolytic activity.

The study examined critical connectivity tissue (human fibroblasts) that had become senescent from oxidative and genotoxic stress. They further tested the flavinoids on mice, evaluating age-related histopathology, disease markers, health span and lifespan.

Of the 10 flavonoids tested, fisetin was the most potent senolytic. When they treated the old mice. Fisetin reduced senescent markers in multiple tissues, consistent with a hit-and-run senolytic treatment like Dasatinib + Quercetin. It was determined that fisetin demonstrates senotherapeutic activity in both human and mice tissue. In mice, it was found that fisetin restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.

Additionally, fisetin is known for its antioxidant properties. It combats oxidative stress, a key contributor to aging and chronic disease, by neutralizing free radicals and reducing oxidative damage. This activity not only helps in slowing down the aging process but also supports cognitive functions, protecting against age-related decline in brain health.

It has been demonstrated that fisetin supports senescence by activating and regulating AMPK, MAPK, and mTOR pathways while also inhibiting CDK1, and CDK4 kinase enzymes. [4] A 2015 study indicated that AMPK activation can delay aging [2], while a 2019 study demonstrated mTOR inhibition has profound effects on life span and age-associated phenotypes across a wide array of organisms. [3]

Natural senolytic supplements are widely available, but notably, NEUROmergence®, which contains fisetin, is formulated with seven additional senotherapeutic agents, to inhibit the same pathways targeted by Dasatinib. NEUROmergence® also contains quercetin to further align it as a true counterpart to the Dasatinib + quercetin treatment.

1. Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652. https://pubmed.ncbi.nlm.nih.gov/30279143/

2. Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941559/

3. Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. mTOR as a central regulator of lifespan and aging. F1000Res. 2019 Jul 2;8:F1000 Faculty Rev-998. doi: 10.12688/f1000research.17196.1. PMID: 31316753; PMCID: PMC6611156.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/

4. Baier A, Szyszka R. Compounds from Natural Sources as Protein Kinase Inhibitors. Biomolecules. 2020 Nov 12;10(11):1546. doi: 10.3390/biom10111546. PMID: 33198400; PMCID: PMC7698043. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698043/

In a recent move that has sparked widespread discussion within the dietary supplement sector, the Council for Responsible Nutrition (CRN) filed a motion for a preliminary injunction to halt the implementation of a New York law imposing age restrictions on the purchase of certain supplements. This legislation, aimed at regulating the sale of weight management and muscle building supplements to individuals under 18, underscores the growing concern over consumer safety and the need for clear, informative labeling in the industry.

We believe this development as a crucial moment for the industry to reflect on the importance of regulation and transparency. While the intended goal of the New York law is to protect young consumers, it also highlights a broader issue: the need for enhanced regulation across the board to ensure that all consumers, regardless of age, are fully informed about the supplements they choose to incorporate into their wellness routines.

As a company at the forefront of supplement research, MDS Labs® has always championed the cause of consumer education and safety. We believe that clearer labeling, comprehensive ingredient disclosure, and stringent product testing are essential to empower consumers to make informed health decisions. This recent legislative attempt in New York, although controversial, serves as a reminder of the critical need for industry-wide standards that prioritize consumer well-being.

As a product developer in this industry, we support the idea that more regulation, particularly in the realm labeling and unsubstantiated medical claims, can benefit the industry by fostering trust and credibility. By ensuring that products on the market are both safe and effectively labeled, we can help consumers navigate the wide array of supplements available, making choices that best suit their health needs and goals.

As the discussion around the New York age restriction law unfolds, MDS Labs® remains committed to advancing the conversation on regulatory reforms. We advocate for measures that not only protect consumers but also support the integrity and innovation that are hallmarks of the dietary supplement industry. Through collaboration with regulatory bodies, industry peers, and consumer advocacy groups, we aim to contribute to the development of policies that ensure safety, transparency, and consumer trust, as we hope to set a new standard from within our own product line, and hope other manufacturers follow suit.