
Pterostilbene, Found in Blueberries, Show Potent Anti-aging Potential by Inhibiting BCR/ABL, Similar to D+Q Senolytic Treatment. Also Shown to Increase the Potency of Metformin and Other Medications.
Categories: Gallery, Uncategorized 0 CommentsPterostilbene, a compound chemically related (dimethyl ether analog) to Resveratrol and found predominantly in Blueberries, has garnered attention for its potential anti-aging benefits. It is prized for its high bioavailability compared to Resveratrol, which means it may be more effective at reaching and benefitting various parts of the body.
Pterostilbene demonstrates significant antioxidant activity, which is crucial in combating oxidative stress, a major factor in the aging process and associated diseases. Oxidative stress results from an imbalance between free radicals and antioxidants in the body, leading to cellular damage. Pterostilbene helps mitigate this damage by scavenging harmful free radicals, thus protecting cellular integrity over time.
Additionally, Pterostilbene has been found to exhibit anti-inflammatory properties. Chronic inflammation is another pathway through which aging accelerates, contributing to various age-related diseases such as cardiovascular disease, diabetes, and Alzheimer’s disease. By reducing inflammation, Pterostilbene could potentially delay the onset of these conditions and extend lifespan.
Furthermore, some studies suggest that Pterostilbene may improve cognitive function and brain health. It appears to enhance pathways involved in brain cell repair and maintenance, which could counteract age-related declines in mental functioning and protect against neurodegenerative diseases.
It has been demonstrated that Pterostilbene supports activation of the AMPK pathway. A 2015 study indicated that AMPK activation can successfully delay aging. [1]. It was also shown that Pterostilbene has significant metobolic properties, and can increase the potency of other medications, including Metformin, Clofibrate, Tamoxifen and the FOXFOX regimen. [2]
Most importantly, Pterostilbene downregulates BRC/ABL pathways. [3] This is why it is a vital component in our NEUROmergence® product, a natural senotherapeutic formulated to inhibit the same pathways as D+Q. D+Q is a potent senolytic that is a combination of Dasatinib and Quercetin, which has demonstrated impressive results in the fight against dementia, cognitive decline, long COVID-19, and age-related pathologies. Interestingly, it has even been shown to reverse Down Syndrome in vitro. “NEUROmergence® is one of the best tools we currently have to support the fight against aging and disease, and it’s something you can buy right now.” – Longevity Guru A. Geller
MDS Labs® offers NEUROmergence in a 30-day supply ($54.50):
https://www.mdslabs.shop/product/neuromergence/
MDS Labs® also offers pure Pterostilbene in both capsule and bulk powder (starting at $28.50):(Includes Pterostilbene, Rutin, Quercetin, Lupeol, Senna, Berberine, Fisetin and Spermidine, all-in-one product)
https://www.mdslabs.shop/product/mcs-labs-pure-pterostilbene-400mg/
[1] Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941559/
[2] Kawakami, S., Tsuma-Kaneko, M., Sawanobori, M. et al. Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells. Sci Rep 12, 704 (2022). https://doi.org/10.1038/s41598-021-04654-1
[3] McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi: 10.1155/2013/575482. Epub 2013 Apr 4. PMID: 23691264; PMCID: PMC3649683. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/