Pure Quercetin
From Sophora japonica
400mg Vegan Capsules
- 99% Pure Quercetin Isolate
- Senolytic & Senomorphic Support*
- Supports Cardiometabolic, Cellular, and Immune Health*
- Supports Cognitive Health & Neuroprotection*
- Natural, Gluten Free, Vegan, Non GMO
Quercetin: A Powerful Flavonoid with Antioxidant and Neuroprotective Properties*
Quercetin is a naturally occurring flavonoid found in many fruits, vegetables, grains, and leaves, and is also found abundantly in onions, apples, berries, and tea. It's known for its antioxidant properties, which are studied for their role in counteracting oxidative stress and inflammation — processes associated with aging.* Human and animal studies have provided supportive evidence for the neuroprotective effects of quercetin, both against neurotoxic chemicals and in various models of neuronal injury.* [1] Quercetin is also one of the two compounds combined in the D+Q senolytic research combination.
It is hypothesized that quercetin may act both as a direct antioxidant and by stimulating the body's own cellular defenses against oxidative stress. Researchers have proposed it does this in part by inducing the Nrf2-ARE and PON2 signaling pathways.* Quercetin has also been shown to activate sirtuins (SIRT1) and to induce autophagy — the process by which the body breaks down and recycles old, damaged, or abnormal cells.* [1]
the Accumulation of Senescent Cells as we Age
As we get older, senescent cells gradually accumulate in the body. These worn-out cells can affect the function of nearby healthy cells, and researchers are studying their role in how the body responds to stress and ages over time. Cellular senescence is an active area of aging research. Senotherapeutics are a rapidly emerging area within that research, studied for their potential to target senescent cells and support healthy tissue renewal. Senotherapeutics are generally divided into two classes, senolytics and senomorphics. [2]
senotherapeutics: senolytics & senomorphics
Senolytics are studied for their ability to selectively target senescent cells. Many known senolytics, such as Dasatinib + Quercetin (D+Q), are thought to act on critical enzymes associated with pro-survival and anti-apoptotic (anti cell death) mechanisms, particularly the Bcl-2 signaling pathway. In research settings, senolytics have been studied in the context of conditions such as atherosclerosis and liver fibrosis. Several natural compounds, including fisetin, curcumin, and piperlongumine, are also being studied for similar properties through various signaling pathways.* [2] Senolytics are considered apoptotic. Apoptosis is a normal biological function in the life cycle of a cell, used by the body to clear cells that are unneeded, abnormal, or damaged beyond repair.
Senomorphics, by contrast, are studied for their ability to reduce the inflammatory signaling secreted by senescent cells. They are thought to act on different enzymes, including NF-kB, IL-1a, MAPK and others. Although less widely discussed than senolytics, they may represent a complementary approach, since senescent cells are also involved in normal processes such as wound healing and development. [2] Several compounds studied as senomorphics, such as Rapamycin (which acts on mTOR, Nrf2, and NF-kB) and Metformin (which acts on mTOR and activates AMPK), are being researched for anti-aging properties.* Rapamycin is noted in the literature as the compound most consistently shown to extend lifespan across mammalian studies. [3] Senomorphics are described as nonapoptotic, since they are thought to work by reducing inflammatory signaling from senescent cells rather than clearing the cells themselves.
Quercetin: Studied as Both a Senolytic and a Senomorphic*
A notable aspect of Quercetin is that it has been studied for both senolytic and senomorphic properties.* Its senomorphic activity is thought to come from its ability to activate proteasomes — barrel-shaped protein complexes that break down unwanted proteins. When a protein is marked for destruction, enzymes tag it with a chemical marker the proteasome recognizes; the proteasome then unfolds the protein and breaks it into pieces the cell can reuse. [4] Quercetin's study as a senolytic comes from research on its ability to inhibit the SRC family kinases (SRC, FYN, LYN), BCL-2, PI3K isoforms, and AKT kinase.* AKT signaling also plays a role in aging research, and one study found that treatment with an AKT inhibitor extended lifespan in a model organism.* [5]
D+Q: The Senolytic Combination That Inspired a Nutritional Approach*
D+Q, the combination of Dasatinib and Quercetin, was first identified through a hypothesis-driven study. D+Q is reported to reduce the burden of senescent cells by targeting the survival pathways (SCAPs) these cells rely on. [2] Early research demonstrated its ability to mitigate age-related dysfunction in mice, and a small 2019 pilot study marked the first time D+Q was given to human participants. [6] More recent preclinical work — in human brain organoids and in mice — has studied senolytics in the context of brain aging and viral neuropathology, with human clinical research still ongoing. [7]
The idea behind NEUROmergence®, a senolytic formulation developed by MDS Labs®, was to bring together well-researched plant compounds studied on senolytic-related pathways, alongside quercetin for its researched senotherapeutic properties.* NEUROmergence® is formulated entirely from compounds with established safety profiles, and is available without a prescription.* The formulation was developed by mapping the kinase targets reported in dasatinib research — BCR-Abl, SRC Family (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), c-KIT (PI3K, AKT, JAK2, STAT3, MAPK), CSF1R, Bcl-2, CDK2, and PDGFR (α and β) — and then selecting natural compounds researched on many of these same pathways, several of which have also been studied for AMPK activation.* A 2015 study examined how AMPK activation relates to the aging process.* [8] Our Quercetin Pure 400mg is a 99% Quercetin Isolate extracted from Sophora japonica — the same form of quercetin used in NEUROmergence®.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Costa LG, Garrick JM, Roquè PJ, Pellacani C. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxid Med Cell Longev. 2016;2016:2986796. doi: 10.1155/2016/2986796. Epub 2016 Jan 24. PMID: 26904161; PMCID: PMC4745323.
https://pubmed.ncbi.nlm.nih.gov/26904161/
[2] Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins, Targeting cellular senescence with senotherapeutics: senolytics and senomorphics, The FEBS Journal, Volume 290, Issue 5, 2022, Pages 1362-1383, ISSN 1742464X,
https://doi.org/10.1111/febs.16350
[3] Zelton Dave Sharp, Randy Strong, Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update, Experimental Gerontology, Volume 176, 2023, 112166, ISSN 0531-5565, https://doi.org/10.1016/j.exger.2023.112166.
https://www.sciencedirect.com/science/article/pii/S0531556523000876
[4] E. Conway de Macario, A.J.L. Macario, Proteases in the Eukaryotic Cell Cytosol, Editor(s): George Fink, Encyclopedia of Stress (Second Edition), Academic Press, 2007, Pages 252-257, ISBN 9780123739476,https://doi.org/10.1016/B978-012373947-6.00708-X.
https://www.sciencedirect.com/science/article/pii/B978012373947600708X
[5] Xingyi Cheng, Meng Xie, Lu Luo, Yao Tian, Guixiang Yu, Qi Wu, Xiaolan Fan, Deying Yang, Xueping Mao, Uma Gaur, Mingyao Yang, Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway, Mechanisms of Ageing and Development, Volume 202, 2022, 111633, ISSN 0047-6374,
https://doi.org/10.1016/j.mad.2022.111633.
https://www.sciencedirect.com/science/article/pii/S004763742200015X
[6] Justice JN, Nambiar AM, Tchkonia T, et al. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 4. PMID: 30616998; PMCID: PMC6412088.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412088/
[7] Aguado J, Amarilla AA, Taherian Fard A, et al. Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nat Aging. 2023;3:1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. PMID: 37957361.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724067/
[8] Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941559/
Pure Quercetin
From Sophora japonica
400mg Vegan Capsules
99% Pure Quercetin Isolate- Senolytic & Senomorphic Support*
- Supports Cardiometabolic, Cellular, and Immune Health*
- Supports Cognitive Health & Neuroprotection*
- Natural, Gluten Free, Vegan, Non GMO
Quercetin: A Powerful Flavonoid with Antioxidant and Neuroprotective Properties*
Quercetin is a naturally occurring flavonoid found in many fruits, vegetables, grains, and leaves, and is also found abundantly in onions, apples, berries, and tea. It’s known for its antioxidant properties, which are studied for their role in counteracting oxidative stress and inflammation — processes associated with aging.* Human and animal studies have provided supportive evidence for the neuroprotective effects of quercetin, both against neurotoxic chemicals and in various models of neuronal injury.* [1] Quercetin is also one of the two compounds combined in the D+Q senolytic research combination.
It is hypothesized that quercetin may act both as a direct antioxidant and by stimulating the body’s own cellular defenses against oxidative stress. Researchers have proposed it does this in part by inducing the Nrf2-ARE and PON2 signaling pathways.* Quercetin has also been shown to activate sirtuins (SIRT1) and to induce autophagy — the process by which the body breaks down and recycles old, damaged, or abnormal cells.* [1]
the Accumulation of Senescent Cells as we Age
As we get older, senescent cells gradually accumulate in the body. These worn-out cells can affect the function of nearby healthy cells, and researchers are studying their role in how the body responds to stress and ages over time. Cellular senescence is an active area of aging research. Senotherapeutics are a rapidly emerging area within that research, studied for their potential to target senescent cells and support healthy tissue renewal. Senotherapeutics are generally divided into two classes, senolytics and senomorphics. [2]
senotherapeutics: senolytics & senomorphics
Senolytics are studied for their ability to selectively target senescent cells. Many known senolytics, such as Dasatinib + Quercetin (D+Q), are thought to act on critical enzymes associated with pro-survival and anti-apoptotic (anti cell death) mechanisms, particularly the Bcl-2 signaling pathway. In research settings, senolytics have been studied in the context of conditions such as atherosclerosis and liver fibrosis. Several natural compounds, including fisetin, curcumin, and piperlongumine, are also being studied for similar properties through various signaling pathways.* [2] Senolytics are considered apoptotic. Apoptosis is a normal biological function in the life cycle of a cell, used by the body to clear cells that are unneeded, abnormal, or damaged beyond repair.
Senomorphics, by contrast, are studied for their ability to reduce the inflammatory signaling secreted by senescent cells. They are thought to act on different enzymes, including NF-kB, IL-1a, MAPK and others. Although less widely discussed than senolytics, they may represent a complementary approach, since senescent cells are also involved in normal processes such as wound healing and development. [2] Several compounds studied as senomorphics, such as Rapamycin (which acts on mTOR, Nrf2, and NF-kB) and Metformin (which acts on mTOR and activates AMPK), are being researched for anti-aging properties.* Rapamycin is noted in the literature as the compound most consistently shown to extend lifespan across mammalian studies. [3] Senomorphics are described as nonapoptotic, since they are thought to work by reducing inflammatory signaling from senescent cells rather than clearing the cells themselves.
Quercetin: Studied as Both a Senolytic and a Senomorphic*
A notable aspect of Quercetin is that it has been studied for both senolytic and senomorphic properties.* Its senomorphic activity is thought to come from its ability to activate proteasomes — barrel-shaped protein complexes that break down unwanted proteins. When a protein is marked for destruction, enzymes tag it with a chemical marker the proteasome recognizes; the proteasome then unfolds the protein and breaks it into pieces the cell can reuse. [4] Quercetin’s study as a senolytic comes from research on its ability to inhibit the SRC family kinases (SRC, FYN, LYN), BCL-2, PI3K isoforms, and AKT kinase.* AKT signaling also plays a role in aging research, and one study found that treatment with an AKT inhibitor extended lifespan in a model organism.* [5]
D+Q: The Senolytic Combination That Inspired a Nutritional Approach*
D+Q, the combination of Dasatinib and Quercetin, was first identified through a hypothesis-driven study. D+Q is reported to reduce the burden of senescent cells by targeting the survival pathways (SCAPs) these cells rely on. [2] Early research demonstrated its ability to mitigate age-related dysfunction in mice, and a small 2019 pilot study marked the first time D+Q was given to human participants. [6] More recent preclinical work — in human brain organoids and in mice — has studied senolytics in the context of brain aging and viral neuropathology, with human clinical research still ongoing. [7]
The idea behind NEUROmergence®, a senolytic formulation developed by MDS Labs®, was to bring together well-researched plant compounds studied on senolytic-related pathways, alongside quercetin for its researched senotherapeutic properties.* NEUROmergence® is formulated entirely from compounds with established safety profiles, and is available without a prescription.* The formulation was developed by mapping the kinase targets reported in dasatinib research — BCR-Abl, SRC Family (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), c-KIT (PI3K, AKT, JAK2, STAT3, MAPK), CSF1R, Bcl-2, CDK2, and PDGFR (α and β) — and then selecting natural compounds researched on many of these same pathways, several of which have also been studied for AMPK activation.* A 2015 study examined how AMPK activation relates to the aging process.* [8] Our Quercetin Pure 400mg is a 99% Quercetin Isolate extracted from Sophora japonica — the same form of quercetin used in NEUROmergence®.*
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. The information contained on this site has not been evaluated by the Food and Drug Administration.
* These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
Please be aware that findings from animal studies and research on human cell lines may not necessarily reflect outcomes observed in humans. We encourage you to do your own research, and consult your physician before taking this or any other dietary supplements.
ABOUT MDS LABS
CITATIONS:
[1] Costa LG, Garrick JM, Roquè PJ, Pellacani C. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxid Med Cell Longev. 2016;2016:2986796. doi: 10.1155/2016/2986796. Epub 2016 Jan 24. PMID: 26904161; PMCID: PMC4745323.
https://pubmed.ncbi.nlm.nih.gov/26904161/
[2] Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins, Targeting cellular senescence with senotherapeutics: senolytics and senomorphics, The FEBS Journal, Volume 290, Issue 5, 2022, Pages 1362-1383, ISSN 1742464X,
https://doi.org/10.1111/febs.16350
[3] Zelton Dave Sharp, Randy Strong, Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update, Experimental Gerontology, Volume 176, 2023, 112166, ISSN 0531-5565, https://doi.org/10.1016/j.exger.2023.112166.
https://www.sciencedirect.com/science/article/pii/S0531556523000876
[4] E. Conway de Macario, A.J.L. Macario, Proteases in the Eukaryotic Cell Cytosol, Editor(s): George Fink, Encyclopedia of Stress (Second Edition), Academic Press, 2007, Pages 252-257, ISBN 9780123739476,https://doi.org/10.1016/B978-012373947-6.00708-X.
https://www.sciencedirect.com/science/article/pii/B978012373947600708X
[5] Xingyi Cheng, Meng Xie, Lu Luo, Yao Tian, Guixiang Yu, Qi Wu, Xiaolan Fan, Deying Yang, Xueping Mao, Uma Gaur, Mingyao Yang, Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway, Mechanisms of Ageing and Development, Volume 202, 2022, 111633, ISSN 0047-6374,
https://doi.org/10.1016/j.mad.2022.111633.
https://www.sciencedirect.com/science/article/pii/S004763742200015X
[6] Justice JN, Nambiar AM, Tchkonia T, et al. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 4. PMID: 30616998; PMCID: PMC6412088.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412088/
[7] Aguado J, Amarilla AA, Taherian Fard A, et al. Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nat Aging. 2023;3:1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. PMID: 37957361.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724067/
[8] Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559.
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